Author's response to reviews Title: The in vitro antifungal activity of flavonoids against Trichophyton rubrum is due to the inhibition of fatty acid synthase and a reduction in ergosterol content Authors:
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Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum
BACKGROUND Fatty acid synthase (FAS) is a promising antifungal target due to its marked structural differences between fungal and mammalian cells. The aim of this study was to evaluate the antifungal activity of flavonoids described in the scientific literature as FAS inhibitors (quercetin, trans-chalcone, ellagic acid, luteolin, galangin, and genistein) against the dermatophyte Trichophyton ru...
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تاریخ انتشار 2012